Targeting protein kinase C in sarcoma
Abstract
Protein kinase C (PKC) is a family of serine/threonine tyrosine kinases that regulate many cellular processes including division, proliferation, survival, anoikis and polarity. PKC is abundant in many human cancers and aberrant PKC signalling has been demonstrated in cancer models. On this basis, PKC has become an attractive target for small molecule inhibition within oncology drug development programmes. Sarcoma is a heterogeneous group of mesenchymal malignancies. Due to their relative insensitivity to conventional chemotherapies and the increasing recognition of the driving molecular events of sarcomagenesis, sarcoma provides an excellent platform to test novel therapeutics. In this review we provide a structure-function overview of the PKC family, the rationale for targeting these kinases in sarcoma and the state of play with regard to PKC inhibition in the clinic.
Journal details
Journal Biochimica et Biophysica Acta
Volume 1846
Issue number 2
Pages 547-559
Publication date
Full text links
Publisher website (DOI) 10.1016/j.bbcan.2014.10.002
Europe PubMed Central 25453364
Pubmed 25453364
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Type of publication