Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heartMore about Open Access at the Crick
Authors listM Sameer Rana Magali Théveniau-Ruissy Christopher De Bono Karim Mesbah Alexandre Francou Mayyasa Rammah Jorge N Domínguez Marine Roux Brigitte Laforest Robert H Anderson Timothy Mohun Stephane Zaffran Vincent M Christoffels Robert G Kelly
Cardiac progenitor cells from the second heart field (SHF) contribute to rapid growth of the embryonic heart, giving rise to right ventricular and outflow tract (OFT) myocardium at the arterial pole of the heart, and atrial myocardium at the venous pole. Recent clonal analysis and cell-tracing experiments indicate that a common progenitor pool in the posterior region of the SHF gives rise to both OFT and atrial myocytes. The mechanisms regulating deployment of this progenitor pool remain unknown.