Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart
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M Sameer Rana Magali Théveniau-Ruissy Christopher De Bono Karim Mesbah Alexandre Francou Mayyasa Rammah Jorge N Domínguez Marine Roux Brigitte Laforest Robert H Anderson Timothy Mohun Stephane Zaffran Vincent M Christoffels Robert G KellyAbstract
Cardiac progenitor cells from the second heart field (SHF) contribute to rapid growth of the embryonic heart, giving rise to right ventricular and outflow tract (OFT) myocardium at the arterial pole of the heart, and atrial myocardium at the venous pole. Recent clonal analysis and cell-tracing experiments indicate that a common progenitor pool in the posterior region of the SHF gives rise to both OFT and atrial myocytes. The mechanisms regulating deployment of this progenitor pool remain unknown.
Journal details
Journal Circulation Research
Volume 115
Issue number 9
Pages 790-799
Publication date
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Publisher website (DOI) 10.1161/circresaha.115.305020
Europe PubMed Central 25190705
Pubmed 25190705
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