The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis
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Simon Blankley Matthew Paul Reddoch Berry Christine Graham Chloe I Bloom Marc Lipman Anne O'GarraAbstract
Despite advances in antimicrobials, vaccination and public health measures, infectious diseases remain a leading cause of morbidity and mortality worldwide. With the increase in antimicrobial resistance and the emergence of new pathogens, there remains a need for new and more accurate diagnostics, the ability to monitor adequate treatment response as well as the ability to predict prognosis for an individual. Transcriptional approaches using blood signatures have enabled a better understanding of the host response to diseases, leading not only to new avenues of basic research, but also to the identification of potential biomarkers for use in diagnosis, prognosis and treatment monitoring.
Journal details
Volume 369
Issue number 1645
Pages 20130427
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Publisher website (DOI) 10.1098/rstb.2013.0427
Europe PubMed Central 24821914
Pubmed 24821914
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