The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition
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Gareth Prosser Brandenburg Julius Norbert Reiling Clifton Earl Barry Robert Wilkinson Katalin WilkinsonAbstract
Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines.
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Journal Microbes and Infection
Volume 19
Issue number 3
Pages 177-192
Available online
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Publisher website (DOI) 10.1016/j.micinf.2016.10.001
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Europe PubMed Central 27780773
Pubmed 27780773
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