The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer
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Attila Marcell Szász Qiyuan Li Aron C Eklund Zsófia Sztupinszki Andrew Rowan Anna-Mária Tökes Borbála Székely András Kiss Miklós Szendrői Balázs Győrffy Zoltán Szállási Charles Swanton Janina KulkaAbstract
Quantifying chromosomal instability (CIN) has both prognostic and predictive clinical utility in breast cancer. In order to establish a robust and clinically applicable gene expression-based measure of CIN, we assessed the ability of four qPCR quantified genes selected from the 70-gene Chromosomal Instability (CIN70) expression signature to stratify outcome in patients with grade 2 breast cancer.
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Publisher website (DOI) 10.1371/journal.pone.0056707
Europe PubMed Central 23468873
Pubmed 23468873
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