The ESCRT machinery: new roles at new holes
Authors listY Olmos Jeremy Carlton
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. These events share the requirement for a topologically equivalent membrane remodeling for their completion and the cells deployment of the ESCRT machinery in these different contexts highlights its functionality as a transposable membrane-fission machinery. Here, we will examine recent data describing ESCRT-III dependent membrane remodeling and explore new roles for the ESCRT-III complex at the nuclear envelope.
Journal Current Opinion in Cell Biology
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Publisher website (DOI) 10.1016/j.ceb.2015.12.001
Europe PubMed Central 26775243
Type of publication