The gammaretroviral p12 protein has multiple domains that function during the early stages of replication
Authors listDarren J Wight Virginie C Boucherit Mirella Nader David J Allen Ian Taylor Kate Bishop
The Moloney murine leukaemia virus (Mo-MLV) gag gene encodes three main structural proteins, matrix, capsid and nucleocapsid and a protein called p12. In addition to its role during the late stages of infection, p12 has an essential, but undefined, function during early post-entry events. As these stages of retroviral infection remain poorly understood, we set out to investigate the function of p12.