The genetic evolution of metastasis
Abstract
Cancer is an evolutionary process that is characterized by the emergence of multiple genetically distinct populations or clones within the primary tumor. Intratumor heterogeneity provides a substrate for the selection of adaptive clones, such as those that lead to metastasis. Comparative molecular studies of primary tumors and metastases have identified distinct genomic features associated with the development of metastases. In this review, we discuss how these insights could inform clinical decision-making and uncover rational antimetastasis treatment strategies.
Journal details
Journal Cancer Research
Volume 82
Issue number 10
Pages 1849-1857
Available online
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Publisher website (DOI) 10.1158/0008-5472.CAN-21-3863
Europe PubMed Central 35476646
Pubmed 35476646
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