The immunopathogenesis of tuberculous pericarditis
Authors listPatrick Howlett Elsa Du Bruyn Hazel Morrison Isiguzo C Godsent Katalin Wilkinson Mpiko Ntsekhe Robert Wilkinson
Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8-34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.
Journal Microbes and Infection
Issue number 4-5