The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland
Authors list
Samira Bell Jacqueline Campbell Emilie Lambourg Chrissie Watters Martin O'Neil Alison Almond Katharine Buck Edward J Carr Laura Clark Zoe Cousland Mark Findlay Nicola Joss Wendy Metcalfe Michaela Petrie Elaine Spalding Jamie P Traynor Vinod Sanu Peter Thomson Shona Methven Patrick B MarkAbstract
Background:
Patients with kidney failure requiring kidney replacement therapy (KRT) are at high risk of complications and death following SARS-CoV-2 infection with variable antibody responses to vaccination reported. We investigated the effects of COVID-19 vaccination on incidence of infection, hospitalization and death of COVID-19 infection.
Methods:
Study design was an observational data linkage cohort study. Multiple healthcare datasets were linked to ascertain all SARS-CoV-2 testing, vaccination, hospitalization, and mortality data for all patients treated with KRT in Scotland, from the start of the pandemic over a period of 20 months. Descriptive statistics, survival analyses, and vaccine effectiveness were calculated.
Results:
As of 19th September 2021, 93% (n=5281) of the established KRT population in Scotland had received two doses of an approved SARS-CoV-2 vaccine. Over the study period, there were 814 cases of SARS-CoV-2 infection (15.1% of the KRT population). Vaccine effectiveness against infection and hospitalization was 33% (95% CI 0-52) and 38% (95% CI 0-57) respectively. 9.2% of fully vaccinated individuals died within 28 days of a SARS-CoV-2 positive PCR test (7% dialysis patients and 10% kidney transplant recipients). This compares to <0.1% of the vaccinated Scottish population being admitted to hospital or dying death due to COVID19 during that period.
Conclusions:
These data demonstrate a primary vaccine course of two doses has limited impact on COVID-19 infection and its complications in patients treated with KRT. Adjunctive strategies to reduce risk of both COVID-19 infection and its complications in this population are urgently required.
Journal details
Volume 33
Issue number 4
Pages 677-686
Available online
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Full text links
Publisher website (DOI) 10.1681/ASN.2022010046
Europe PubMed Central 35110363
Pubmed 35110363
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