The interface between transcription and mechanisms maintaining genome integrity


Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication.

Journal details

Volume 35
Issue number 6
Pages 333-338
Publication date


Type of publication

Crick labs/facilities