The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS

More about Open Access at the Crick


RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways.

Journal details

Journal Antioxidants
Volume 10
Issue number 4
Pages 552
Available online
Publication date


Type of publication