The N- and C-terminal ends of RPGR can bind to PDE6δ

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This study shows that the prenylated C‐terminus of RPGR can bind to PDE6δ with high affinity, suggesting two distinct binding sites of the RPGR/PDE6δ complex. The serine residue at the −3 position relative to the prenylated cysteine seems to play a key role in defining the selectivity of PDE6δ towards ciliary prenylated cargo. [Image: see text]

Journal details

Journal EMBO Reports
Volume 16
Issue number 12
Pages 1583-1585
Available online
Publication date

Crick labs/facilities