The possible impact of vaccination for seasonal influenza on emergence of pandemic influenza via reassortment
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Xu-Sheng Zhang Richard Pebody Daniela De Angelis Peter J White Andre Charlett John MccauleyAbstract
One pathway through which pandemic influenza strains might emerge is reassortment from coinfection of different influenza A viruses. Seasonal influenza vaccines are designed to target the circulating strains, which intuitively decreases the prevalence of coinfection and the chance of pandemic emergence due to reassortment. However, individual-based analyses on 2009 pandemic influenza show that the previous seasonal vaccination may increase the risk of pandemic A(H1N1) pdm09 infection. In view of pandemic influenza preparedness, it is essential to understand the overall effect of seasonal vaccination on pandemic emergence via reassortment.
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Publisher website (DOI) 10.1371/journal.pone.0114637
Europe PubMed Central 25494180
Pubmed 25494180
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