The quid pro quo of the tumor/stromal interaction


Cancers can derive metabolic support from the stromal cells that surround them. A new study in Cell Metabolism (Yang et al., 2016) describes how ovarian cancer cells can satisfy their need for glutamine by stimulating glutamine production in adjacent fibroblasts, highlighting a metabolic dependence that might be targeted for therapy.

Journal details

Journal Cell Metabolism
Volume 24
Issue number 5
Pages 645-646
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Crick authors

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