The quid pro quo of the tumor/stromal interaction
Abstract
Cancers can derive metabolic support from the stromal cells that surround them. A new study in Cell Metabolism (Yang et al., 2016) describes how ovarian cancer cells can satisfy their need for glutamine by stimulating glutamine production in adjacent fibroblasts, highlighting a metabolic dependence that might be targeted for therapy.
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Publisher website (DOI) 10.1016/j.cmet.2016.10.017
Europe PubMed Central 27829131
Pubmed 27829131
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