The role of ubiquitin modification in the regulation of p53
Abstract
The p53 tumor suppressor protein is involved in regulating a wide variety of stress responses, from senescence and apoptosis to more recently discovered roles in allowing adaptation to metabolic and oxidative stress. After 34years of research, significant progress has been made in unraveling the complexity of the p53 network, and it is clear that the regulation of p53 protein stability is critical in the control of p53 activity. This article focuses on our current understanding of how the level and activity of p53 is controlled by this seemingly simple mechanism. This article is part of a Special Issue entitled: Ubiquitin-Proteasome System. Guest Editors: Thomas Sommer and Dieter H. Wolf.
Journal details
Journal Biochimica et Biophysica Acta
Volume 1843
Issue number 1
Pages 137-149
Publication date
Full text links
Publisher website (DOI) 10.1016/j.bbamcr.2013.05.022
Europe PubMed Central 23742843
Pubmed 23742843
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Type of publication