The subclonal architecture of metastatic breast cancer: results from a prospective community-based rapid autopsy program "CASCADE"
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Peter Savas Zhi Ling Teo Christophe Lefevre Christoffer Flensburg Franco Caramia Kathryn Alsop Mariam Mansour Prudence A Francis Heather A Thorne Maria Joao Silva Nnennaya Kanu Michelle Dietzen Andrew Rowan Maik Kschischo Stephen Fox David D Bowtell Sarah-Jane Dawson Terence P Speed Charles Swanton Sherene LoiAbstract
Understanding the cancer genome is seen as a key step in improving outcomes for cancer patients. Genomic assays are emerging as a possible avenue to personalised medicine in breast cancer. However, evolution of the cancer genome during the natural history of breast cancer is largely unknown, as is the profile of disease at death. We sought to study in detail these aspects of advanced breast cancers that have resulted in lethal disease.
Journal details
Journal PLOS Medicine
Volume 13
Issue number 12
Pages e1002204
Available online
Publication date
Full text links
Publisher website (DOI) 10.1371/journal.pmed.1002204
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Europe PubMed Central 28027312
Pubmed 28027312