The Toxoplasma parasitophorous vacuole: an evolving host-parasite frontier
Authors list
Barbara Clough Eva-Maria FrickelAbstract
The parasitophorous vacuole is a unique replicative niche for apicomplexan parasites, including Toxoplasma gondii. Derived from host plasma membrane, the vacuole is rendered nonfusogenic with the host endolysosomal system. Toxoplasma secretes numerous proteins to modify the forming vacuole, enable nutrient uptake, and set up mechanisms of host subversion. Here we describe the pathways of host-parasite interaction at the parasitophorous vacuole employed by Toxoplasma and host, leading to the intricate balance of host defence versus parasite survival.
Journal details
Journal Trends in Parasitology
Volume 33
Issue number 6
Pages 473-488
Publication date
Full text links
Publisher website (DOI) 10.1016/j.pt.2017.02.007
Europe PubMed Central 28330745
Pubmed 28330745
Keywords
Related topics
Type of publication