The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling


Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult. The aim of the present study was to define Pw1 expression in the embryonic and adult pancreas and investigate its role in the beta cell cycle in Pw1 wild-type and mutant mice.

Journal details

Journal Diabetologia
Volume 59
Issue number 7
Pages 1474-1479
Available online
Publication date