Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancersMore about Open Access at the Crick
Authors listEdurne Mugarza Febe Van Maldegem Jesse Boumelha Christopher Moore Sareena Rana Miriam Llorian Sopena Phil East Rachel Ambler Panos Anastasiou Pablo Romero-Clavijo Karishma Valand Megan Cole Miriam Molina Arcas Julian Downward
Recently developed KRASG12C inhibitory drugs are beneficial to lung cancer patients harboring KRASG12C mutations, but drug resistance frequently develops. Because of the immunosuppressive nature of the signaling network controlled by oncogenic KRAS, these drugs can indirectly affect antitumor immunity, providing a rationale for their combination with immune checkpoint blockade. In this study, we have characterized how KRASG12C inhibition reverses immunosuppression driven by oncogenic KRAS in a number of preclinical lung cancer models with varying levels of immunogenicity. Mechanistically, KRASG12C inhibition up-regulates interferon signaling via Myc inhibition, leading to reduced tumor infiltration by immunosuppressive cells, enhanced infiltration and activation of cytotoxic T cells, and increased antigen presentation. However, the combination of KRASG12C inhibitors with immune checkpoint blockade only provides synergistic benefit in the most immunogenic tumor model. KRASG12C inhibition fails to sensitize cold tumors to immunotherapy, with implications for the design of clinical trials combining KRASG12C inhibitors with anti-PD1 drugs.
Journal Science advances
Issue number 29