Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinoma
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J Miles CJ Applebee P Leboucher S Lopez-Fernandez DJ Lee R Guarch S Ward Peter Parker JI López B LarijaniAbstract
Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these adenocarcinomas is essential. The dysregulation of the oncoprotein, PKB/Akt has been linked with poor prognoses in human cancers.
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Publisher website (DOI) 10.1016/j.bbacli.2017.10.002
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Europe PubMed Central 29296589
Pubmed 29296589
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