Time resolved amplified FRET identifies protein kinase B activation state as a marker for poor prognosis in clear cell renal cell carcinomaMore about Open Access at the Crick
Authors listJ Miles CJ Applebee P Leboucher S Lopez-Fernandez DJ Lee R Guarch S Ward Peter Parker JI López B Larijani
Clear cell Renal Cell Carcinomas (ccRCC), the largest group of renal tumours, are resistant to classical therapies. The determination of the functional state of actionable biomarkers for the assessment of these adenocarcinomas is essential. The dysregulation of the oncoprotein, PKB/Akt has been linked with poor prognoses in human cancers.
Journal BBA Clinical