Tissue architecture in tumor initiation and progression
More about Open Access at the CrickAbstract
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.
Journal details
Journal Trends in Cancer
Volume 8
Issue number 6
Pages 494-505
Available online
Publication date
Full text links
Publisher website (DOI) 10.1016/j.trecan.2022.02.007
Europe PubMed Central 35300951
Pubmed 35300951
Keywords
Related topics
Type of publication