Tissue-engineering the intestine: The trials before the trials.

Journal Article: Cell Stem CellYear Published: (2019) Volume Number: 24, Article Number: 855-859

Authors

Clevers,Hans; Conder,Ryan K; Li,Vivian SW; Lutolf,Matthias P; Vallier,Ludovic; Chan,Sarah; Grikscheit,Tracy C; Jensen,Kim B; De Coppi,Paolo

Building complex tissues requires the development of innovative interdisciplinary engineering solutions. In this Forum, the INTENS Consortium discuss experimental considerations and challenges for generating a tissue-engineered intestine for the treatment of short bowel syndrome, taking into account cell source, scaffold choice, and design strategy for achieving proper assembly and function.