Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system

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The enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity is created within the embryonic ENS; information required for development of cell-based therapies and models of enteric neuropathies. We aimed to identify proteins that regulate ENS differentiation and network formation.

Journal details

Volume 154
Issue number 3
Pages 624-636
Available online
Publication date