Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signalingMore about Open Access at the Crick
Authors listCarlos Talavera-López Barbara Capuccini Richard Mitter Jing Wen Lin Jean Langhorne
Plasmodium berghei ANKA infection in mice is a model for human cerebral malaria, the most severe complication of Plasmodium falciparum infection. Responses of brain microglia have been little investigated, and may contribute to the pathogenesis of cerebral malaria. We showed previously that microglia are activated in P. berghei infections, and that Type 1-Interferon signaling is important for activation. This dataset compares transcriptomic profiles of brain microglia of infected mice in the presence and absence of Type 1 interferon signaling, with the aim of identifying genes in microglia in this pathway during experimental cerebral malaria.
Journal BMC Research Notes
Issue number 1