Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling
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Carlos Talavera-López Barbara Capuccini Richard Mitter Jing Wen Lin Jean LanghorneAbstract
Plasmodium berghei ANKA infection in mice is a model for human cerebral malaria, the most severe complication of Plasmodium falciparum infection. Responses of brain microglia have been little investigated, and may contribute to the pathogenesis of cerebral malaria. We showed previously that microglia are activated in P. berghei infections, and that Type 1-Interferon signaling is important for activation. This dataset compares transcriptomic profiles of brain microglia of infected mice in the presence and absence of Type 1 interferon signaling, with the aim of identifying genes in microglia in this pathway during experimental cerebral malaria.
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Journal BMC Research Notes
Volume 11
Issue number 1
Pages 913
Available online
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Publisher website (DOI) 10.1186/s13104-018-4020-3
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Europe PubMed Central 30572937
Pubmed 30572937
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