Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism
More about Open Access at the CrickAuthors list
Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L Burke Acely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B Young Robert WilkinsonAbstract
Although a few studies have described the microbiome composition of TB sputa based on 16S ribosomal DNA, these studies did not compare to non-TB samples and the nature of the method does not allow any functional inference. This is the first study to apply such technology using clinical specimens and obtained functional transcriptional data on all three aspects simultaneously.
Journal details
Journal mBio
Volume 12
Issue number 6
Pages e01766-21
Available online
Publication date
Full text links
Publisher website (DOI) 10.1128/mbio.01766-21
Europe PubMed Central 34872348
Pubmed 34872348
Keywords
Related topics
Type of publication