Tumor suppression by p53: fall of the triumvirate?

Abstract

p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.

Journal details

Journal Cell
Volume 149
Issue number 6
Pages 1183-1185
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Crick authors

Crick First author
Crick Corresponding author