Two negatives make a positive for insulin secretion and growth

Journal Article: Developmental CellYear Published: (2019) Volume Number: 48, Article Number: 11-12


Sawala,Annick; Gould,Alex P

The confusingly named growth-blocking peptides are nutrient-dependent adipokines that stimulate insulin secretion and boost growth in developing flies. In this issue of Developmental Cell, Meschi et al. (2018) show that these adipose tissue-derived factors regulate insulin secretion by silencing a pair of inhibitory neurons that synapse with insulin-producing cells.