Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast
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Laura Gatti Kwang L Hoe Jacqueline Hayles Sabina C Righetti Nives Carenini Laura Dal Bo Dong U Kim Han O Park Paola PeregoAbstract
The ubiquitin(Ub)-proteasome pathway is implicated in the regulation of a variety of cellular functions and plays a major role in stress response in eukaryotic cells, by targeting misfolded and damaged proteins for degradation. In addition, in the presence of DNA damage, the Ub-proteasome system regulates proteins involved in sensing, repairing, and/or tolerating the damage. Antitumor agents such as cisplatin can activate the pathway, but the role of specific pathway components in cell sensitivity/response to the drug is not known. Since platinum compounds represent clinically relevant antitumor agents and a major limitation to their use is the development of drug resistance, there is an urgent need for identifying targets for improving their efficacy.
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Publisher website (DOI) 10.1186/1471-2164-12-44
Europe PubMed Central 21247416
Pubmed 21247416
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