Understanding and intervening in HIV-associated tuberculosis
Abstract
HIV-associated tuberculosis can present as extremes, ranging from acute life-threatening disseminated disease to occult asymptomatic infection. Both ends of this spectrum have distinct pathological correlates and require specific diagnostic and treatment approaches. Novel therapeutics, targeting both pathogen and host, are needed to augment pathogen clearance. In latent tuberculosis infection, enhancement of immune activation could be desirable. Antiretroviral therapy augments the beneficial effects of antitubercular therapy. However, in the context of high bacillary burden, antiretroviral therapy can also result in pathology (tuberculosis immune reconstitution inflammatory syndrome). In the immune reconstituting patient, modulation of immune activation controls tissue destruction. Interventions should also be appropriate and sustainable within the programmatic setting.
Journal details
Journal Clinical Medicine
Volume 15
Issue number Suppl 6
Pages s43-s49
Publication date
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Publisher website (DOI) 10.7861/clinmedicine.15-6-s43
Europe PubMed Central 26634681
Pubmed 26634681
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