Understanding eukaryotic chromosome segregation from a comparative biology perspective
Abstract
A long-appreciated variation in fundamental cell biological processes between different species is becoming increasingly tractable due to recent breakthroughs in whole-genome analyses and genome editing techniques. However, the bulk of our mechanistic understanding in cell biology continues to come from just a few well-established models. In this Review, I use the highly diverse strategies of chromosome segregation in eukaryotes as an instrument for a more general discussion on phenotypic variation, possible rules underlying its emergence and its utility in understanding conserved functional relationships underlying this process. Such a comparative approach, supported by modern molecular biology tools, might provide a wider, holistic view of biology that is difficult to achieve when concentrating on a single experimental system.
Journal details
Journal Journal of Cell Science
Volume 131
Issue number 14
Pages jcs203653
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Publisher website (DOI) 10.1242/jcs.203653
Europe PubMed Central 30030298
Pubmed 30030298
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