Understanding the impact of immune-mediated selection on lung cancer evolution
Authors listRachel Rosenthal Charles Swanton Nicholas McGranahan
Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.
Journal British Journal of Cancer