Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts


High throughput screening (HTS) is one of the primary tools used to identify novel enzyme inhibitors. However, its applicability is generally restricted to targets that can either be expressed recombinantly or purified in large quantities.

Journal details

Journal PLOS ONE
Volume 5
Issue number 8
Pages e11985
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Type of publication