VE-cadherin-mediated epigenetic regulation of endothelial gene expressionMore about Open Access at the Crick
Authors listMarco F Morini Costanza Giampietro Monica Corada Federica Pisati Elisa Lavarone Sara I Cunha Lei L Conze Nicola O'Reilly Dhira Joshi Svend Kjaer Roger George Emma Nye Anqi Ma Jian Jin Richard Mitter Michela Lupia Ugo Cavallaro Diego Pasini Dinis Calado Elisabetta Dejana Andrea Taddei
The mechanistic foundation of vascular maturation is still largely unknown. Several human pathologies are characterized by deregulated angiogenesis and unstable blood vessels. Solid tumors, for instance, get their nourishment from newly formed structurally abnormal vessels which present wide and irregular interendothelial junctions. Expression and clustering of the main endothelial-specific adherens junction protein, VEC (vascular endothelial cadherin), upregulate genes with key roles in endothelial differentiation and stability.
Journal Circulation Research
Issue number 2