Visualising the cardiovascular system of embryos of biomedical model organisms with high resolution episcopic microscopy (HREM)
More about Open Access at the CrickAuthors list
Wolfgang J Weninger Barbara Maurer-Gesek Lukas F Reissig Fabrice Prin Robert Wilson Antonella Galli David J Adams Jacqueline K White Timothy J Mohun Stefan H GeyerAbstract
The article will briefly introduce the high-resolution episcopic microscopy (HREM) technique and will focus on its potential for researching cardiovascular development and remodelling in embryos of biomedical model organisms. It will demonstrate the capacity of HREM for analysing the cardiovascular system of normally developed and genetically or experimentally malformed zebrafish, frog, chick and mouse embryos in the context of the whole specimen and will exemplarily show the possibilities HREM offers for comprehensive visualisation of the vasculature of adult human skin. Finally, it will provide examples of the successful application of HREM for identifying cardiovascular malformations in genetically altered mouse embryos produced in the deciphering the mechanisms of developmental disorders (DMDD) program.
Journal details
Volume 5
Issue number 4
Pages 58
Available online
Publication date
Full text links
Publisher website (DOI) 10.3390/jcdd5040058
Figshare View on figshare
Europe PubMed Central 30558275
Pubmed 30558275
Keywords
Related topics
Type of publication