White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathiesMore about Open Access at the Crick
Authors listAlan J Burns Allan M Goldstein Donald F Newgreen Lincon Stamp Karl-Herbert Schäfer Marco Metzger Ryo Hotta Heather M Young Peter W Andrews Nikhil Thapar Jaime Belkind-Gerson Nadege Bondurand Joel C Bornstein Wood Yee Chan Kathryn Cheah Michael D Gershon Robert O Heuckeroth Robert MW Hofstra Lothar Just Raj P Kapur Sebastian K King Conor J McCann Nandor Nagy Elly Ngan Florian Obermayr Vassilis Pachnis Pankaj J Pasricha Mai Har Sham Paul Tam Pieter Vanden Berghe
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Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.
Journal Developmental Biology
Issue number 2