Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?


The sequence of a large number of MHC-presented epitopes is not present as such in the original antigen because it has been re-shuffled by the proteasome or other proteases. Why do proteases throw a spanner in the works of our model of antigen tagging and immune recognition? We describe in this review what we know about the immunological relevance of post-translationally spliced epitopes and why proteases seem to have a second (dark) personality, which is keen to create new peptide bonds.

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Volume 52
Pages 81-86
Available online
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Crick authors

Crick First author
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