WNK1 kinase balances T cell adhesion versus migration in vivo
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Robert Koechl Flavian Thelen Lesley Vanes Tiago F Brazão Kathryn Fountain Jian Xie Chou-Long Huang Ruth Lyck Jens V Stein Victor TybulewiczAbstract
Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2. WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them. Our results reveal that a pathway previously known only to regulate salt homeostasis in the kidney functions to balance T cell adhesion and migration.
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Journal Nature Immunology
Volume 17
Issue number 9
Pages 1075-1083
Available online
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Publisher website (DOI) 10.1038/ni.3495
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Europe PubMed Central 27400149
Pubmed 27400149
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