YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signalingMore about Open Access at the Crick
Authors listRalph Gruber Richard Panayiotou Emma Nye Bradley Spencer-Dene Gordon Stamp Axel Behrens
Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)-a precursor of pancreatic intraepithelial neoplasia lesions that can progress to PDAC. Mutations in KRAS are found at the earliest stages of pancreatic tumorigenesis, and it appears to be a gatekeeper to cancer progression. We investigated how mutations in KRAS cooperate with pancreatitis to promote pancreatic cancer progression in mice.
Issue number 3