WWW Consortium

The WWW Consortium brings together three studies of healthy adults in West Africa, the West Indies and West London who have received COVID-19 vaccines.
A hand holding a tray of samples being tested for COVID-19.

Intro

The WWW Consortium aims to answer fundamental questions about the immunology of SARS-CoV-2 variants by bringing together three prospective cohort studies of healthy adults in West Africa, the West Indies and West London who have received COVID-19 vaccines.

Even though there are similarities between the populations in the three locations, like shared genetic ancestry and common vaccines, COVID-19 has shown dramatically different outcomes in each location.

We are working to identify mechanisms behind these differences by combining information and approaches from the three studies. We hope to provide insights into the factors that affect immunity to SARS-CoV-2 variants that can also inform future pandemic response in regions currently underserved by both research and surveillance capacity.

  • Location
    Francis Crick Institute, London, UK
    London School of Hygiene and Tropical Medicine, London, UK
    University College London Hospital, London, UK
    West African Centre for Cell Biology of Infectious Pathogens, Accra, Ghana
    University of the West Indies, St Augustine, Trinidad & Tobago
    University of the West Indies, Mona, Jamaica

We have three aims:

  • 1. Investigate the breadth of immunity to SARS-CoV-2 variants across the three cohorts by standardising the three studies, including transferring assay and modelling capacity between the three locations.

  • 2. Test four hypotheses on factors that might contribute to differences within and between our cohorts:

    • Exposure to earlier SARS-CoV-2 variants
    • Exposure to other bat and human coronaviruses
    • Exposure to malaria
    • Inflammation and other immune reactions following vaccination

  • 3. Build individual-level models of immune responses to predict immunity to SARS-CoV-2 variants in low- and middle- income countries, with an emphasis on determining the minimum set of data required in each instance, and deploying models for local use.

  • West Africa, West Indies, West London Consortium.

    About the studies

    Studies

    Find out more about the people behind the consortium on the WWW Consortium team page.

    WWW Consortium team

    Heritage

    A collaborative study by Yemaachi Biotech, WACCBIP and the Ghana Health Service studying vaccine responses in Ghanian adults vaccinated against SARS-CoV-2.

    📍 Accra, Ghana | Led by Yaw Bediako

    Legacy

    A study of SARS-CoV-2 immunity that builds upon a partnership established early in the pandemic between University College London Hospitals and the Crick.

    📍 London, UK | Led by Emma Wall

    Windfall

    A study following vaccinated and unvaccinated cohorts from across the West Indies, monitoring immune responses to vaccines and SARS-CoV-2 variants.

    📍 Kingston, Jamaica | Led by Joshua Anzinger

    Consortium partners

    Map of the North Atlantic region with locations identified by organisation logos. London UK - the Francis Crick Institute, London School of Hygiene and Tropic Medicine, and UCLH NHS Trust. Accra, Ghana - WACCBIP and Yemaachi Biotechnology. Kingston, Jamaica and St Augustine, Trinidad & Tobago - University of the West Indies.

    Consortium partner logos

    Crick logo
    London School of Hygiene and Tropical Medicine
    University College London Hospitals NHS Foundation Trust
    University of the West Indies.
    University Hospital of the West Indies
    WACCBIP logo
    Yemaachi Biotech
    Find out more about the people behind the consortium on the WWW Consortium team page.
    WWW Consortium team >