The WWW Consortium aims to answer fundamental questions about the immunology of SARS-CoV-2 variants by bringing together three prospective cohort studies of healthy adults in West Africa, the West Indies and West London who have received COVID-19 vaccines.
Even though there are similarities between the populations in the three locations, like shared genetic ancestry and common vaccines, COVID-19 has shown dramatically different outcomes in each location.
We are working to identify mechanisms behind these differences by combining information and approaches from the three studies. We hope to provide insights into the factors that affect immunity to SARS-CoV-2 variants that can also inform future pandemic response in regions currently underserved by both research and surveillance capacity.
• Francis Crick Institute, London, UK
• London School of Hygiene and Tropical Medicine, London, UK
• University College London Hospital, London, UK
• West African Centre for Cell Biology of Infectious Pathogens, Accra, Ghana
• University of the West Indies, St Augustine, Trinidad & Tobago
• University of the West Indies, Mona, Jamaica
We have three aims:
1. Investigate the breadth of immunity to SARS-CoV-2 variants across the three cohorts by standardising the three studies, including transferring assay and modelling capacity between the three locations.
2. Test four hypotheses on factors that might contribute to differences within and between our cohorts:
• Exposure to earlier SARS-CoV-2 variants
• Exposure to other bat and human coronaviruses
• Exposure to malaria
• Inflammation and other immune reactions following vaccination
3. Build individual-level models of immune responses to predict immunity to SARS-CoV-2 variants in low- and middle- income countries, with an emphasis on determining the minimum set of data required in each instance, and deploying models for local use.
About the studies
A collaborative study by Yemaachi Biotech, WACCBIP and the Ghana Health Service studying vaccine responses in Ghanian adults vaccinated against SARS-CoV-2.
📍 Accra, Ghana | Led by Yaw Bediako
A study of SARS-CoV-2 immunity that builds upon a partnership established early in the pandemic between University College London Hospitals and the Crick.
📍 London, UK | Led by Emma Wall
A study following vaccinated and unvaccinated cohorts from across the West Indies, monitoring immune responses to vaccines and SARS-CoV-2 variants.