Vaccine Composition

WHO recommendations on the compositions of influenza vaccines are based on the available data on the antigenic and genetic characteristics of recently circulating viruses and antibody responses to recent vaccines.

September 2017

In September 2017, the WHO recommended that influenza vaccines in use for the influenza season (southern hemisphere winter) contain:

  • an A/Michigan/45/2015 (H1N1)pdm09-like virus;
  • an A/Singapore/INFIMH-16-0019/2016 (H3N2)-like virus;
  • a B/Phuket/3073/2013-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virus.

The recommendation has been published in the  Weekly Epidemiological Record Vol 92, 625-633

February/March 2017

February/March 2017

In March 2017, the WHO recommended that influenza vaccines in use for the 2017/2018 influenza season (northern hemisphere winter) contain:

  • an A/Michigan/45/2015 (H1N1)pdm09-like virus;
  • an A/Hong Kong/4801/2014 (H3N2)-like virus;
  • a B/Brisbane/60/2008-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Phuket/3073/2013-like virus.

The recommendation has been published in the  Weekly Epidemiological Record Vol 92, 117-128.

September 2016

In September 2016, the WHO recommended that influenza vaccines in use for the 2017 influenza season (southern hemisphere winter) contain:

  • an A/Michigan/45/2015 (H1N1)pdm09-like virus;
  • an A/Hong Kong/4801/2014 (H3N2)-like virus;
  • a B/Brisbane/60/2008-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Phuket/3073/2013-like virus.

The report has been published in the Weekly Epidemiological Record Vol 91, 469-484.

February 2016

In February 2016, the WHO recommended that influenza vaccines in use for the 2016/2017 influenza season (northern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Hong Kong/4801/2014 (H3N2)-like virus;
  • a B/Brisbane/60/2008-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Phuket/3073/2013-like virus.

The report is available  online and has been published in the Weekly Epidemiological Record Vol 91, 121-132. 

September 2015

In September 2015, the WHO recommended that influenza vaccines in use for the 2016 influenza season (southern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Hong Kong/4801/2014 (H3N2)-like virus;
  • a B/Brisbane/60/2008-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Phuket/3073/2013-like virus.

The report is available online and has been published in the Weekly Epidemiological Record Vol 90, 561-576. 

February 2015

In February 2015, the WHO recommended that influenza vaccines in use for the 2015/2016 influenza season (northern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Switzerland/9715293/2013 (H3N2)-like virus;
  • a B/Phuket/3073/2013-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virus.

The report is available online and has been published in the Weekly Epidemiological Record Vol 90, 93-104.

September 2014

In September 2013 the WHO recommended that trivalent vaccines for use in the 2014 influenza season (southern hemisphere winter) contain the following:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Switzerland/9715293/2013 (H3N2)-like virus;
  • a B/Phuket/3073/2013-like virus.

It was recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virus.

The report has been published in the Weekly Epidemiological Record Vol 89, 441-456

February 2014

In February 2014, the WHO recommended that influenza vaccines in use for the 2014/2015 influenza season (northern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Texas/50/2012 (H3N2)-like virus;
  • a B/Massachusetts/2/2012-like virus.

It was also recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virus.

The report has been published in the Weekly Epidemiological Record Vol 89, 105-116.

September 2013

In September 2013 the WHO recommended that trivalent vaccines for use in the 2014 influenza season (southern hemisphere winter) contain the following:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Texas/50/2012 (H3N2)-like virus;
  • a B/Massachusetts/2/2012-like virus.

It was recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virus.

The report was published in the Weekly Epidemiological Record Vol 88, 437-448

February 2013

In February 2013 the WHO recommended that trivalent vaccines for use in the 2013-14 influenza season (northern hemisphere winter) contain the following:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A(H3N2) virus antigenically like the cell-propagated prototype virus A/Victoria/361/2011;
  • a B/Massachusetts/2/2012-like virus.

It was recommended that quadrivalent vaccines containing two influenza B viruses contain the above three viruses and a B/Brisbane/60/2008-like virusc.

The report was published in the Weekly Epidemiological Record Vol 88, 101-116

September 2012

In September 2012 the WHO recommended that vaccines for use in the 2012 influenza season (southern hemisphere) contain the following:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Perth/16/2009 (H3N2)-like virus; -
  • a B/Brisbane/60/2008-like virus.

The report was published in the Weekly Epidemiological Record Vol 87, 389-400

February 2012

In February 2012 WHO recommended that vaccines for use in the 2012-2013 influenza season (northern hemisphere winter) contain the following:

  • an A/California/7/2009 (H1N1)pdm09-like virus;
  • an A/Victoria/361/2011 (H3N2)-like virus;
  • a B/Wisconsin/1/2010-like virus.

The report was published in the Weekly Epidemiological Record Vol 87, 81-96

September 2011

In September 2011, the WHO recommended that influenza vaccines in use for the 2012 influenza season (southern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)-like virus an A/Perth/16/2009 (H3N2)-like virus a B/Brisbane/60/2008-like virus (WER 2011, 86, 457-468: Weekly Epidemiological Record)

Weekly Epidemiological Record 86, 457-468. Recommended composition of influenza vaccines for use in the 2012 southern hemisphere influenza season.

February 2011

In February 2011, the WHO recommended that influenza vaccines in use for the 2011-2012 influenza season (northern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)-like virus
  • an A/Perth/16/2009 (H3N2)-like virus
  • a B/Brisbane/60/2008-like virus (WER 2011, 86, 81-91: Weekly Epidemiological Record)

Weekly Epidemiological Record 86, 81-91 Recommended composition of influenza virus vaccines for use in the 2011-2012 northern hemisphere influenza season.

September 2010

In September 2010, the WHO recommended that influenza vaccines for use in the 2011 influenza season (southern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)-like virus
  • an A/Perth/16/2009 (H3N2)-like virus
  • a B/Brisbane/60/2008-like virus

(WER 2010, 85, 401-412: Weekly Epidemiological Record)

February 2010

In February 2010, the WHO recommended that influenza vaccines for use in the 2010/2011 influenza season (northern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)-like virus
  • an A/Perth/16/2009 (H3N2)-like virus
  • a B/Brisbane/60/2008-like virus

(WER 2010, 85, 81-92: Weekly Epidemiological Record)

September 2009

In September 2009, the WHO recommended that influenza vaccines for use in the 2010 influenza season (southern hemisphere winter) contain:

  • an A/California/7/2009 (H1N1)-like virus
  • an A/Perth/16/2009 (H3N2)-like virus
  • a B/Brisbane/60/2008-like virus

(WER 2009, 84, 421-432; Weekly Epidemiological Record)

February 2009

In February 2009, the WHO recommended that influenza vaccines for use in the 2009 - 2010 influenza season (northern hemisphere winter) contain:

  • an A/Brisbane/59/2007 (H1N1)-like virus
  • A/South Dakota/6/2007 (an A/Brisbane/59/2007-like virus) is a current vaccine virus used in live attenuated vaccines
  • an A/Brisbane/10/2007 (H3N2)-like virus
  • A/Brisbane/10/2007 and A/Uruguay/716/2007 (an A/Brisbane/10/2007-like virus) are current vaccine viruses
  • a B/Brisbane/60/2008-like virus
  • B/Brisbane/33/2008 is a B/Brisbane/60/2008-like virus

(WER 2009, 84, 65-72; Weekly Epidemiological Record)

Contacts

whocc@crick.ac.uk
Tel: +44 (0)203 796 0563

Dr John McCauley
(Director of WIC)
john.mccauley@crick.ac.uk
Tel: +44 (0)203 796 1520

Dr Rod Daniels
(Deputy Director)
rod.daniels@crick.ac.uk
Tel: +44 (0)203 796 2444

Dr Yi Pu Lin 
(Assistant Director)
yipu.lin@crick.ac.uk
Tel: +44 (0)203 796 1508