Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 13463 Results Found The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts Authors (6)Minghao ChiaCai Li Sueli Marques Vicente PelechanoNicholas LuscombeFolkert Van Werven Genome Biology Published 14 January 2021 Crick labsFolkert van WervenNicholas LuscombeFull details Dendritic cells revisited Authors (5)Maria Del Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation Authors (13) Pablo Largo-Barrientos Nuno Apóstolo Eline Creemers Zsuzsanna Callaerts-Vegh Jef Swerts Caitlin Davies[...]Bart De Strooper Tara Spires-Jones Joris de Wit Valerie Uytterhoeven Patrik Verstreken Neuron Published 3 March 2021 Crick labsBart de Strooper | Lorena ArancibiaFull details Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein Authors (12) Lydia Horndler Pilar Delgado David Abia Ivaylo Balabanov Pedro Martínez-Fleta Georgina Cornish[...] Sergio Serrano-Villar Francisco Sánchez-Madrid Manuel Fresno Hisse M van Santen Balbino Alarcón EMBO Molecular Medicine Published 5 March 2021 Crick labs/ facilitiesGeorge KassiotisStructural BiologyFull details A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer Authors (21) Hongchen CaiSuKit Chew Chuan Li Min K Tsai Laura Andrejka Christopher W Murray[...] Le Cong Christopher D McFarland Dmitri A PetrovCharles Swanton Monte M Winslow Cancer Discovery Published 1 July 2021 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models Authors (13) Justin L Tosh Elena R Rhymes Paige Mumford Heather T Whittaker Laura J Pulford Sue J Noy[...] Matthew C Walker Victor LJ Tybulewicz Rob C Wykes Elizabeth MC Fisher Frances K Wiseman Scientific Reports Published 11 March 2021 Crick labsVictor TybulewiczFull details A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome Authors (10) Nicolas ToussaintYushi Redhead Marta Vidal-García Lucas Lo Vercio Wei Liu Elizabeth MC Fisher Benedikt HallgrímssonVictor Tybulewicz Julia A Schnabel Jeremy BA Green Development Published 15 September 2021 Crick labsVictor TybulewiczFull details Ultra-fast proteomics with Scanning SWATH Authors (19)Christoph MessnerVadim Demichev Nic Bloomfield Jason SL Yu Matthew White Marco Kreidl[...] Florian Kurth Kathryn S Lilley Michael Mülleder Stephen TateMarkus Ralser Nature Biotechnology Published 1 July 2021 Crick labsMarkus RalserFull details Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 Authors (9) Omar M KhanJorge AlmagroJessica Nelson Stuart Horswell Vesela Encheva Kripa S Keyan Bruce E ClurmanBram SnijdersAxel Behrens Nature Communications Published 6 April 2021 Crick labs/ facilitiesAxel BehrensProteomicsBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous … Page 998 Page 999 Page 1000 Page 1001 Current page 1002 Page 1003 Page 1004 Page 1005 Page 1006 … Next page Next Last page Last
The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details
High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts Authors (6)Minghao ChiaCai Li Sueli Marques Vicente PelechanoNicholas LuscombeFolkert Van Werven Genome Biology Published 14 January 2021 Crick labsFolkert van WervenNicholas LuscombeFull details
Dendritic cells revisited Authors (5)Maria Del Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation Authors (13) Pablo Largo-Barrientos Nuno Apóstolo Eline Creemers Zsuzsanna Callaerts-Vegh Jef Swerts Caitlin Davies[...]Bart De Strooper Tara Spires-Jones Joris de Wit Valerie Uytterhoeven Patrik Verstreken Neuron Published 3 March 2021 Crick labsBart de Strooper | Lorena ArancibiaFull details
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS-CoV-2 spike protein Authors (12) Lydia Horndler Pilar Delgado David Abia Ivaylo Balabanov Pedro Martínez-Fleta Georgina Cornish[...] Sergio Serrano-Villar Francisco Sánchez-Madrid Manuel Fresno Hisse M van Santen Balbino Alarcón EMBO Molecular Medicine Published 5 March 2021 Crick labs/ facilitiesGeorge KassiotisStructural BiologyFull details
A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer Authors (21) Hongchen CaiSuKit Chew Chuan Li Min K Tsai Laura Andrejka Christopher W Murray[...] Le Cong Christopher D McFarland Dmitri A PetrovCharles Swanton Monte M Winslow Cancer Discovery Published 1 July 2021 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models Authors (13) Justin L Tosh Elena R Rhymes Paige Mumford Heather T Whittaker Laura J Pulford Sue J Noy[...] Matthew C Walker Victor LJ Tybulewicz Rob C Wykes Elizabeth MC Fisher Frances K Wiseman Scientific Reports Published 11 March 2021 Crick labsVictor TybulewiczFull details
A landmark-free morphometrics pipeline for high-resolution phenotyping: application to a mouse model of Down syndrome Authors (10) Nicolas ToussaintYushi Redhead Marta Vidal-García Lucas Lo Vercio Wei Liu Elizabeth MC Fisher Benedikt HallgrímssonVictor Tybulewicz Julia A Schnabel Jeremy BA Green Development Published 15 September 2021 Crick labsVictor TybulewiczFull details
Ultra-fast proteomics with Scanning SWATH Authors (19)Christoph MessnerVadim Demichev Nic Bloomfield Jason SL Yu Matthew White Marco Kreidl[...] Florian Kurth Kathryn S Lilley Michael Mülleder Stephen TateMarkus Ralser Nature Biotechnology Published 1 July 2021 Crick labsMarkus RalserFull details
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12 Authors (9) Omar M KhanJorge AlmagroJessica Nelson Stuart Horswell Vesela Encheva Kripa S Keyan Bruce E ClurmanBram SnijdersAxel Behrens Nature Communications Published 6 April 2021 Crick labs/ facilitiesAxel BehrensProteomicsBioinformatics and BiostatisticsFull details
