Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 406 Results Found ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication Authors (6)Guy PearsonHarriet MearsMalgorzata BroncelBram SnijdersDavid LV BauerJeremy Carlton Science advances Published 3 April 2024 Crick labs/ facilitiesJeremy CarltonDavid LV BauerProteomicsLight MicroscopyFull details Monitoring populations at increased risk for SARS-CoV-2 infection in the community using population-level demographic and behavioural surveillance Authors (20) E Pritchard J Jones KD Vihta N StoesserPhilippa Matthews DW Eyre[...] I Diamond T Peto KB Pouwels AS Walker COVID-19 Infection Survey Team The Lancet Regional Health - Europe Published 1 February 2022 Crick labsPhilippa MatthewsFull details Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details T cell responses to SARS-CoV-2 spike cross-recognize Omicron Authors (47) Roanne Keeton Marius B Tincho Amkele Ngomti Richard Baguma Ntombi Benede Akiko Suzuki[...] Penny L Moore Alex Sigal Ntobeko AB Ntusi Wendy A Burgers Catherine Riou Nature Published 17 March 2022 Crick labsRobert J WilkinsonFull details Light Microscopy | Latest news News and information from the Light Microscopy STP. Breadcrumb Research Platforms & facilities Light Microscopy Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections Authors (19) David W Eyre Sheila F Lumley Denise O'Donnell Nicole E StoesserPhilippa Matthews Alison Howarth[...] Derrick W Crook Christopher P Conlon Katie Jeffery Timothy M Walker Timothy EA Peto BMC Infectious Diseases Published 18 February 2021 Crick labsPhilippa MatthewsFull details Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort Authors (22) PD Kirwan VJ Hall S Foulkes AD Otter K Munro D Sparkes[...] SIREN Study Group AM Presanis A Charlett D De Angelis S Hopkins The Lancet Regional Health - Europe Published 1 January 2024 Crick labsRupert BealeFull details Pagination First page First Previous page Previous … Page 26 Page 27 Page 28 Page 29 Current page 30 Page 31 Page 32 Page 33 Page 34 … Next page Next Last page Last
ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication Authors (6)Guy PearsonHarriet MearsMalgorzata BroncelBram SnijdersDavid LV BauerJeremy Carlton Science advances Published 3 April 2024 Crick labs/ facilitiesJeremy CarltonDavid LV BauerProteomicsLight MicroscopyFull details
Monitoring populations at increased risk for SARS-CoV-2 infection in the community using population-level demographic and behavioural surveillance Authors (20) E Pritchard J Jones KD Vihta N StoesserPhilippa Matthews DW Eyre[...] I Diamond T Peto KB Pouwels AS Walker COVID-19 Infection Survey Team The Lancet Regional Health - Europe Published 1 February 2022 Crick labsPhilippa MatthewsFull details
Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
T cell responses to SARS-CoV-2 spike cross-recognize Omicron Authors (47) Roanne Keeton Marius B Tincho Amkele Ngomti Richard Baguma Ntombi Benede Akiko Suzuki[...] Penny L Moore Alex Sigal Ntobeko AB Ntusi Wendy A Burgers Catherine Riou Nature Published 17 March 2022 Crick labsRobert J WilkinsonFull details
Light Microscopy | Latest news News and information from the Light Microscopy STP. Breadcrumb Research Platforms & facilities Light Microscopy
Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections Authors (19) David W Eyre Sheila F Lumley Denise O'Donnell Nicole E StoesserPhilippa Matthews Alison Howarth[...] Derrick W Crook Christopher P Conlon Katie Jeffery Timothy M Walker Timothy EA Peto BMC Infectious Diseases Published 18 February 2021 Crick labsPhilippa MatthewsFull details
Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort Authors (22) PD Kirwan VJ Hall S Foulkes AD Otter K Munro D Sparkes[...] SIREN Study Group AM Presanis A Charlett D De Angelis S Hopkins The Lancet Regional Health - Europe Published 1 January 2024 Crick labsRupert BealeFull details