Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 2540 Results Found Cancer heterogeneity and "the struggle for existence": diagnostic and analytical challenges Authors (3) Stuart Horswell Nicholas MatthewsCharles Swanton Cancer Letters Published 1 November 2013 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Cell signalling and protein phosphorylation: a new type of ‘switch’ Published: 14 October 2016 Breadcrumb News & reports A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer Authors (21) Hongchen CaiSuKit Chew Chuan Li Min K Tsai Laura Andrejka Christopher W Murray[...] Le Cong Christopher D McFarland Dmitri A PetrovCharles Swanton Monte M Winslow Cancer Discovery Published 1 July 2021 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates Authors (27) Claudia Buhigas Anne Y Warren Wing-Kit Leung Hayley C Whitaker Hayley J Luxton Steve Hawkins[...] Andy G Lynch Rosalind A Eeles Colin S Cooper David C Wedge Daniel S Brewer Molecular Cancer Published 22 September 2022 Crick labsPeter Van LooFull details Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival Authors (8) Susana Ros Claudio R Santos Sofia Moco Franziska BaenkeGavin KellyMichael Howell Nicola Zamboni Almut Schulze Cancer Discovery Published 1 April 2012 Crick labs/ facilitiesHigh Throughput ScreeningBioinformatics and BiostatisticsFull details RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance Authors (17) Daniël A LionaronsDavid HancockSareena RanaPhil EastChristopher MooreMiguel Murillo[...]Ian Rosewell Ralph Fritsch Richard NeubigMiriam Molina ArcasJulian Downward Cancer Cell Published 8 July 2019 Crick labs/ facilitiesJulian DownwardDinis CaladoGenetic Modification ServiceExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details Pagination First page First Previous page Previous … Page 60 Page 61 Page 62 Page 63 Current page 64 Page 65 Page 66 Page 67 Page 68 … Next page Next Last page Last
Cancer heterogeneity and "the struggle for existence": diagnostic and analytical challenges Authors (3) Stuart Horswell Nicholas MatthewsCharles Swanton Cancer Letters Published 1 November 2013 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Cell signalling and protein phosphorylation: a new type of ‘switch’ Published: 14 October 2016 Breadcrumb News & reports
A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer Authors (21) Hongchen CaiSuKit Chew Chuan Li Min K Tsai Laura Andrejka Christopher W Murray[...] Le Cong Christopher D McFarland Dmitri A PetrovCharles Swanton Monte M Winslow Cancer Discovery Published 1 July 2021 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization Authors (12)Emma NolanVicky BridgemanLuigi OmbratoAdam KaroutasNick Rabas Celine Angeli Natascha Sewnath[...]Felipe Rodrigues Stuart HorswellPeter Faull Rebecca CarterIlaria Malanchi Nature Cancer Published 1 February 2022 Crick labs/ facilitiesIlaria MalanchiProteomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates Authors (27) Claudia Buhigas Anne Y Warren Wing-Kit Leung Hayley C Whitaker Hayley J Luxton Steve Hawkins[...] Andy G Lynch Rosalind A Eeles Colin S Cooper David C Wedge Daniel S Brewer Molecular Cancer Published 22 September 2022 Crick labsPeter Van LooFull details
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival Authors (8) Susana Ros Claudio R Santos Sofia Moco Franziska BaenkeGavin KellyMichael Howell Nicola Zamboni Almut Schulze Cancer Discovery Published 1 April 2012 Crick labs/ facilitiesHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance Authors (17) Daniël A LionaronsDavid HancockSareena RanaPhil EastChristopher MooreMiguel Murillo[...]Ian Rosewell Ralph Fritsch Richard NeubigMiriam Molina ArcasJulian Downward Cancer Cell Published 8 July 2019 Crick labs/ facilitiesJulian DownwardDinis CaladoGenetic Modification ServiceExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details
Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details
