Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 2543 Results Found Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival Authors (8) Susana Ros Claudio R Santos Sofia Moco Franziska BaenkeGavin KellyMichael Howell Nicola Zamboni Almut Schulze Cancer Discovery Published 1 April 2012 Crick labs/ facilitiesHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance Authors (17) Daniël A LionaronsDavid HancockSareena RanaPhil EastChristopher MooreMiguel Murillo[...]Ian Rosewell Ralph Fritsch Richard NeubigMiriam Molina ArcasJulian Downward Cancer Cell Published 8 July 2019 Crick labs/ facilitiesJulian DownwardDinis CaladoGenetic Modification ServiceExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details Evaluation of cell-free DNA approaches for multi-cancer early detection Authors (49) Arash Jamshidi Minetta C Liu Eric A Klein Oliver Venn Earl Hubbell John F Beausang[...] Mikkael A Sekeres Alan Bryce Alexander M Aravanis Michael V SeidenCharles Swanton Cancer Cell Published 12 December 2022 Crick labsCharles SwantonFull details Genomic evolution of breast cancer metastasis and relapse Authors (30) Lucy R Yates Stian Knappskog David Wedge James HR Farmery Santiago Gonzalez Inigo Martincorena[...] John W Martens Andrea L Richardson Andrew Tutt Per Eystein Lønning Peter J Campbell Cancer Cell Published 14 August 2017 Crick labsPeter Van LooFull details Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer Authors (20) Elza C de Bruin Catherine Cowell Patricia H Warne Ming Jiang Rebecca E Saunders Mary Ann Melnick[...] Harold Varmus René Bernards Egbert F Smit Katerina PolitiJulian Downward Cancer Discovery Published 1 May 2014 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Authors (11)Anastasiya KazachenkaJane LoongJan AttigGeorge YoungPiyali Ganguli Ginny Devonshire Nicola Grehan The OCCAMS ConsortiumFrancesca Ciccarelli Rebecca C FitzgeraldGeorge Kassiotis NAR Cancer Published 1 September 2023 Crick labs/ facilitiesGeorge KassiotisFrancesca CiccarelliBioinformatics and BiostatisticsScientific computingCell ServicesAdvanced SequencingFull details Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes Authors (42) Simon Heeke Carl M Gay Marcos R Estecio Hai Tran Benjamin B Morris Bingnan Zhang[...]Peter Van Loo Jing Wang Ignacio I Wistuba Lauren A Byers John V Heymach Cancer Cell Published 12 February 2024 Crick labsPeter Van LooFull details Leveraging the dynamic immune environment triad in patients with breast cancer: Tumour, lymph node, and peripheral blood Authors (9) Isobelle Wall Victoire Boulat Aekta Shah Kim RM Blenman Yin Wu Elena AlbertsDinis Calado Roberto Salgado Anita Grigoriadis Cancers (Basel) Published 17 September 2022 Crick labsDinis CaladoFull details Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments Authors (24) Barrie Peck Zachary T Schug Qifeng Zhang Beatrice Dankworth Dylan T Jones Elizabeth Smethurst[...] Hing Y Leung Adrian L Harris Michael JO Wakelam Eyal Gottlieb Almut Schulze Cancer & Metabolism Published 1 April 2016 Crick labs/ facilitiesHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous … Page 61 Page 62 Page 63 Page 64 Current page 65 Page 66 Page 67 Page 68 Page 69 … Next page Next Last page Last
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival Authors (8) Susana Ros Claudio R Santos Sofia Moco Franziska BaenkeGavin KellyMichael Howell Nicola Zamboni Almut Schulze Cancer Discovery Published 1 April 2012 Crick labs/ facilitiesHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details
RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance Authors (17) Daniël A LionaronsDavid HancockSareena RanaPhil EastChristopher MooreMiguel Murillo[...]Ian Rosewell Ralph Fritsch Richard NeubigMiriam Molina ArcasJulian Downward Cancer Cell Published 8 July 2019 Crick labs/ facilitiesJulian DownwardDinis CaladoGenetic Modification ServiceExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsFull details
Evaluation of cell-free DNA approaches for multi-cancer early detection Authors (49) Arash Jamshidi Minetta C Liu Eric A Klein Oliver Venn Earl Hubbell John F Beausang[...] Mikkael A Sekeres Alan Bryce Alexander M Aravanis Michael V SeidenCharles Swanton Cancer Cell Published 12 December 2022 Crick labsCharles SwantonFull details
Genomic evolution of breast cancer metastasis and relapse Authors (30) Lucy R Yates Stian Knappskog David Wedge James HR Farmery Santiago Gonzalez Inigo Martincorena[...] John W Martens Andrea L Richardson Andrew Tutt Per Eystein Lønning Peter J Campbell Cancer Cell Published 14 August 2017 Crick labsPeter Van LooFull details
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer Authors (20) Elza C de Bruin Catherine Cowell Patricia H Warne Ming Jiang Rebecca E Saunders Mary Ann Melnick[...] Harold Varmus René Bernards Egbert F Smit Katerina PolitiJulian Downward Cancer Discovery Published 1 May 2014 Crick labs/ facilitiesJulian DownwardHigh Throughput ScreeningFull details
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Authors (11)Anastasiya KazachenkaJane LoongJan AttigGeorge YoungPiyali Ganguli Ginny Devonshire Nicola Grehan The OCCAMS ConsortiumFrancesca Ciccarelli Rebecca C FitzgeraldGeorge Kassiotis NAR Cancer Published 1 September 2023 Crick labs/ facilitiesGeorge KassiotisFrancesca CiccarelliBioinformatics and BiostatisticsScientific computingCell ServicesAdvanced SequencingFull details
Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes Authors (42) Simon Heeke Carl M Gay Marcos R Estecio Hai Tran Benjamin B Morris Bingnan Zhang[...]Peter Van Loo Jing Wang Ignacio I Wistuba Lauren A Byers John V Heymach Cancer Cell Published 12 February 2024 Crick labsPeter Van LooFull details
Leveraging the dynamic immune environment triad in patients with breast cancer: Tumour, lymph node, and peripheral blood Authors (9) Isobelle Wall Victoire Boulat Aekta Shah Kim RM Blenman Yin Wu Elena AlbertsDinis Calado Roberto Salgado Anita Grigoriadis Cancers (Basel) Published 17 September 2022 Crick labsDinis CaladoFull details
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments Authors (24) Barrie Peck Zachary T Schug Qifeng Zhang Beatrice Dankworth Dylan T Jones Elizabeth Smethurst[...] Hing Y Leung Adrian L Harris Michael JO Wakelam Eyal Gottlieb Almut Schulze Cancer & Metabolism Published 1 April 2016 Crick labs/ facilitiesHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsFull details
