Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 719 Results Found Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling Authors (9)Peter Kreuzaler Matthew A Clarke Elizabeth J Brown Catherine H Wilson Roderik M Kortlever Nir Piterman Trevor LittlewoodGerard Evan Jasmin Fisher Proceedings of the National Academy of Sciences of USA Published 29 October 2019 Crick labsGerard EvanFull details A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse Authors (18) Leo M Carlin Rachel Evans Hanna Milewicz Luis Fernandes Daniel R Matthews Michela Perani[...] Franca Fraternali Simon Ameer-BegPeter Parker N Shaun B Thomas Tony Ng Science Signaling Published 1 January 2011 Crick labsPeter ParkerFull details A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay Authors (10) G Cairns F Burté R Price E O’Connor M Toms R MishraMariya Moosajee A Pyle JA Sayer P Yu-Wai-Man Scientific Reports Published 14 October 2021 Crick labsMariya MoosajeeFull details TAF4b transcription networks regulating early oocyte differentiation Authors (9) Megan A Gura Soňa Relovská Kimberly M Abt Kimberly A Seymour Tong WuHaskan KayaJames Turner Thomas G Fazzio Richard N Freiman Development Published 1 February 2022 Crick labsJames TurnerFull details The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms Authors (19) Luke J Fulcher Polyxeni Bozatzi Theresa Tachie-Menson Kevin ZL Wu Timothy D Cummins Joshua C Bufton[...] David G Campbell Kevin DingwellJim Smith Alex N Bullock Gopal P Sapkota Science Signaling Published 22 May 2018 Crick labsJim SmithFull details Resolution of single and double Holliday junction recombination intermediates by GEN1 Authors (5)Rajvee Shah Punatar Maria Jose Martin Haley DM WyattYing Wai ChanStephen West Proceedings of the National Academy of Sciences of the United States of America Published 17 January 2017 Crick labsStephen WestFull details Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation Authors (7) Daniel Ramírez Montero Humberto Sánchez Edo van Veen Theo van Laar Belén SolanoJohn Diffley Nynke H Dekker Nature Communications Published 14 April 2023 Crick labsJohn DiffleyFull details NFIX regulates proliferation and migration within the murine SVZ neurogenic niche Authors (16) Yee Hsieh Evelyn Heng Bo ZhouLachlan Harris Tracey Harvey Aaron Smith Elise Horne[...] Richard M Gronostajski Giles S YeoFrancois Guillemot Timothy L Bailey Michael Piper Cerebral Cortex Published 1 October 2015 Crick labsFrancois GuillemotFull details MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development Authors (7)Patrick Costello Mathew Sargent Diane Maurice Cyril Esnault Katie FosterFernando Dos Anjos AfonsoRichard Treisman Blood Published 19 February 2015 Crick labsRichard TreismanDominique BonnetFull details Community-wide experimental evaluation of the PROSS stability-design method Authors (33) Yoav Peleg Renaud Vincentelli Brett M Collins Kai-En Chen Emma K Livingstone Saroja Weeratunga[...] Peggy Stolt-Bergner Christian Aigner Sabine Suppmann Adi Goldenzweig Sarel J Fleishman Journal of Molecular Biology Published 25 June 2021 Crick labs/ facilitiesStructural BiologyFull details Pagination First page First Previous page Previous … Page 22 Page 23 Page 24 Page 25 Current page 26 Page 27 Page 28 Page 29 Page 30 … Next page Next Last page Last
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling Authors (9)Peter Kreuzaler Matthew A Clarke Elizabeth J Brown Catherine H Wilson Roderik M Kortlever Nir Piterman Trevor LittlewoodGerard Evan Jasmin Fisher Proceedings of the National Academy of Sciences of USA Published 29 October 2019 Crick labsGerard EvanFull details
A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse Authors (18) Leo M Carlin Rachel Evans Hanna Milewicz Luis Fernandes Daniel R Matthews Michela Perani[...] Franca Fraternali Simon Ameer-BegPeter Parker N Shaun B Thomas Tony Ng Science Signaling Published 1 January 2011 Crick labsPeter ParkerFull details
A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay Authors (10) G Cairns F Burté R Price E O’Connor M Toms R MishraMariya Moosajee A Pyle JA Sayer P Yu-Wai-Man Scientific Reports Published 14 October 2021 Crick labsMariya MoosajeeFull details
TAF4b transcription networks regulating early oocyte differentiation Authors (9) Megan A Gura Soňa Relovská Kimberly M Abt Kimberly A Seymour Tong WuHaskan KayaJames Turner Thomas G Fazzio Richard N Freiman Development Published 1 February 2022 Crick labsJames TurnerFull details
The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms Authors (19) Luke J Fulcher Polyxeni Bozatzi Theresa Tachie-Menson Kevin ZL Wu Timothy D Cummins Joshua C Bufton[...] David G Campbell Kevin DingwellJim Smith Alex N Bullock Gopal P Sapkota Science Signaling Published 22 May 2018 Crick labsJim SmithFull details
Resolution of single and double Holliday junction recombination intermediates by GEN1 Authors (5)Rajvee Shah Punatar Maria Jose Martin Haley DM WyattYing Wai ChanStephen West Proceedings of the National Academy of Sciences of the United States of America Published 17 January 2017 Crick labsStephen WestFull details
Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation Authors (7) Daniel Ramírez Montero Humberto Sánchez Edo van Veen Theo van Laar Belén SolanoJohn Diffley Nynke H Dekker Nature Communications Published 14 April 2023 Crick labsJohn DiffleyFull details
NFIX regulates proliferation and migration within the murine SVZ neurogenic niche Authors (16) Yee Hsieh Evelyn Heng Bo ZhouLachlan Harris Tracey Harvey Aaron Smith Elise Horne[...] Richard M Gronostajski Giles S YeoFrancois Guillemot Timothy L Bailey Michael Piper Cerebral Cortex Published 1 October 2015 Crick labsFrancois GuillemotFull details
MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development Authors (7)Patrick Costello Mathew Sargent Diane Maurice Cyril Esnault Katie FosterFernando Dos Anjos AfonsoRichard Treisman Blood Published 19 February 2015 Crick labsRichard TreismanDominique BonnetFull details
Community-wide experimental evaluation of the PROSS stability-design method Authors (33) Yoav Peleg Renaud Vincentelli Brett M Collins Kai-En Chen Emma K Livingstone Saroja Weeratunga[...] Peggy Stolt-Bergner Christian Aigner Sabine Suppmann Adi Goldenzweig Sarel J Fleishman Journal of Molecular Biology Published 25 June 2021 Crick labs/ facilitiesStructural BiologyFull details