Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 719 Results Found New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images Authors (5) Ilya Patrushev Christina James-Zorn Aldo Ciau-Uitz Roger Patient Michael J Gilchrist PLoS Computational Biology Published 29 August 2018Full details Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe Authors (3) Shriparna SarbajnaDerek DaviesStephen West Genes & Development Published 15 May 2014 Crick labs/ facilitiesStephen WestFlow CytometryFull details Isomerization of BRCA1-BARD1 promotes replication fork protection Authors (17) Manuel Daza-Martin Katarzyna Starowicz Mohammed Jamshad Stephanie Tye George E Ronson Hannah L MacKay[...] Grant S Stewart Thomas J McCorvieXiaodong Zhang Ruth M Densham Joanna R Morris Nature Published 25 July 2019 Crick labsXiaodong ZhangFull details Unique spectrum of activity of prosimian TRIM5α against exogenous and endogenous retroviruses Authors (11) N RahmMelvyn Yap J Snoeck V Zoete M Munoz U Radespiel E Zimmermann O MichielinJonathan Stoye A Ciuffi A Telenti Journal of Virology Published 1 May 2011 Crick labsJonathan StoyeFull details Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses Authors (5)Melvyn YapGeorge Young Renata Varnaite Serge MorandJonathan Stoye PLOS Genetics Published 11 June 2020 Crick labsJonathan StoyeFull details Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice Authors (14) Julia Grizenkova Shaheen Akhtar Holger Hummerich Andrew Tomlinson Emmanuel A Asante Adam Wenborn[...] Elizabeth MC FisherVictor Tybulewicz Sebastian Brandner John Collinge Sarah E Lloyd Proceedings of the National Academy of Sciences of the United States of America Published 6 August 2012 Crick labsVictor TybulewiczFull details Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers Authors (7)Jeannine Hess Huaiyi Huang Adrian Kaiser Vanessa Pierroz Olivier Blacque Hui Chao Gilles Gasser Chemistry Published 21 July 2017 Crick labsJeannine HessFull details The first steps in the life of a worm: Themes and variations in asymmetric division in C. elegans and other nematodes Authors (2) Marie DelattreNathan Goehring Current Topics in Developmental Biology Published 1 January 2021 Crick labsNathan GoehringFull details Tetherin promotes the innate and adaptive cell–mediated immune response against retrovirus infection in vivo Authors (9) Sam X Li Bradley S Barrett Karl J Heilman Ronald J Messer Rachel A Liberatore Paul D BieniaszGeorge Kassiotis Kim J Hasenkrug Mario L Santiago Journal of Immunology Published 28 May 2014 Crick labsGeorge KassiotisFull details Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine Authors (20) Eleftheria Lamprianidou Chryssoula KordellaAnastasiya Kazachenka Emmanouela Zoulia Elsa Bernard Anastasia Filia[...] Anastasia ChatzidimitriouGeorge Kassiotis Elli Papaemmanuil Ioannis Mitroulis Ioannis Kotsianidis Blood Advances Published 12 January 2021 Crick labsGeorge KassiotisFull details Pagination First page First Previous page Previous … Page 42 Page 43 Page 44 Page 45 Current page 46 Page 47 Page 48 Page 49 Page 50 … Next page Next Last page Last
New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images Authors (5) Ilya Patrushev Christina James-Zorn Aldo Ciau-Uitz Roger Patient Michael J Gilchrist PLoS Computational Biology Published 29 August 2018Full details
Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe Authors (3) Shriparna SarbajnaDerek DaviesStephen West Genes & Development Published 15 May 2014 Crick labs/ facilitiesStephen WestFlow CytometryFull details
Isomerization of BRCA1-BARD1 promotes replication fork protection Authors (17) Manuel Daza-Martin Katarzyna Starowicz Mohammed Jamshad Stephanie Tye George E Ronson Hannah L MacKay[...] Grant S Stewart Thomas J McCorvieXiaodong Zhang Ruth M Densham Joanna R Morris Nature Published 25 July 2019 Crick labsXiaodong ZhangFull details
Unique spectrum of activity of prosimian TRIM5α against exogenous and endogenous retroviruses Authors (11) N RahmMelvyn Yap J Snoeck V Zoete M Munoz U Radespiel E Zimmermann O MichielinJonathan Stoye A Ciuffi A Telenti Journal of Virology Published 1 May 2011 Crick labsJonathan StoyeFull details
Duplication and divergence of the retrovirus restriction gene Fv1 in Mus caroli allows protection from multiple retroviruses Authors (5)Melvyn YapGeorge Young Renata Varnaite Serge MorandJonathan Stoye PLOS Genetics Published 11 June 2020 Crick labsJonathan StoyeFull details
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice Authors (14) Julia Grizenkova Shaheen Akhtar Holger Hummerich Andrew Tomlinson Emmanuel A Asante Adam Wenborn[...] Elizabeth MC FisherVictor Tybulewicz Sebastian Brandner John Collinge Sarah E Lloyd Proceedings of the National Academy of Sciences of the United States of America Published 6 August 2012 Crick labsVictor TybulewiczFull details
Evaluation of the medicinal potential of two ruthenium(II) polypyridine complexes as one- and two-photon photodynamic therapy photosensitizers Authors (7)Jeannine Hess Huaiyi Huang Adrian Kaiser Vanessa Pierroz Olivier Blacque Hui Chao Gilles Gasser Chemistry Published 21 July 2017 Crick labsJeannine HessFull details
The first steps in the life of a worm: Themes and variations in asymmetric division in C. elegans and other nematodes Authors (2) Marie DelattreNathan Goehring Current Topics in Developmental Biology Published 1 January 2021 Crick labsNathan GoehringFull details
Tetherin promotes the innate and adaptive cell–mediated immune response against retrovirus infection in vivo Authors (9) Sam X Li Bradley S Barrett Karl J Heilman Ronald J Messer Rachel A Liberatore Paul D BieniaszGeorge Kassiotis Kim J Hasenkrug Mario L Santiago Journal of Immunology Published 28 May 2014 Crick labsGeorge KassiotisFull details
Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3− T cells represents a potential antitumor mechanism of azacitidine Authors (20) Eleftheria Lamprianidou Chryssoula KordellaAnastasiya Kazachenka Emmanouela Zoulia Elsa Bernard Anastasia Filia[...] Anastasia ChatzidimitriouGeorge Kassiotis Elli Papaemmanuil Ioannis Mitroulis Ioannis Kotsianidis Blood Advances Published 12 January 2021 Crick labsGeorge KassiotisFull details