Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Search Results Fulltext search 719 Results Found Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome Authors (9) Jared R Thomas Jonathan LaCombe Rachel LongEva Lana-Elola Sheona Watson-Scales Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Bone Published 1 July 2020 Crick labsVictor TybulewiczFull details Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018 Authors (18) Emi Takashita Rod S Daniels Seiichiro Fujisaki Vicki Gregory Larisa V Gubareva Weiijuan Huang[...] Herman Tse Dayan Wang Hui-Ling Yen Wenqing Zhang Adam Meijer Antiviral Research Published 1 March 2020 Crick labs/ facilitiesNicola LewisWorldwide Influenza CentreFull details Tʜ17 cells transdifferentiate into regulatory T cells during resolution of inflammation Authors (23) Nicola Gagliani Maria Carolina Amezcua Vesely Andrea Iseppon Leonie Brockmann Hao Xu Noah W Palm[...] Jens GeginatBrigitta Stockinger Enric Esplugues Samuel Huber Richard A Flavell Nature Published 9 July 2015 Crick labsGitta StockingerFull details Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation Authors (15) Motti Gerlic Benjamin Faustin Antonio Postigo Eric Chi-Wang Yu Martina Proell Naran Gombosuren[...] Arnold Satterthwait Robert C Liddington Shahram Salek-Ardakani Shu-ichi Matsuzawa John C Reed Proceedings of the National Academy of Sciences of the United States of America Published 7 May 2013 Crick labsMichael WayFull details Increased skin papilloma formation in mice lacking glutathione transferase GSTP Authors (5) Colin J Henderson Kenneth J Ritchie Aileen McLaren Probir Chakravarty C Roland Wolf Cancer Research Published 15 November 2011 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1) Authors (2)Eachan Johnson Luet-Lok Wong Catalysis Science and Technology Published 21 October 2016 Crick labsEachan JohnsonFull details Optimisation of b-values for the accurate estimation of the apparent diffusion coefficient (ADC) in whole-body diffusion-weighted MRI in patients with metastatic melanoma Authors (9) Annemarie K Knill Matthew D Blackledge Andra Curcean James LarkinSamra Turajlic Angela Riddell Dow Mu Koh Christina Messiou Jessica M Winfield European Radiology Published 1 February 2023 Crick labsSamra TurajlicFull details Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's Authors (20) Christina E Toomey Wendy E HeywoodJames Evans Joanne Lachica Sarah N Pressey Sandrine C Foti[...] Tammaryn Lashley Steve M Gentleman Tamas Revesz Kevin MillsSonia Gandhi Acta Neuropathologica Communications Published 8 September 2022 Crick labsSonia GandhiFull details Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies Authors (8) Anna Olivieri Christine R Collins Fiona HackettChrislaine Withers-Martinez Joshua Marshall Helen R FlynnMark SkehelMichael Blackman PLOS Pathogens Published 1 December 2011 Crick labsMike BlackmanFull details A genetic model for central chondrosarcoma evolution correlates with patient outcome Authors (23) William Cross Iben LyskjærTom LesluyesSteven Hargreaves Anna-Christina Strobl Christopher Davies[...] Genomics England Research Consortium Paul Cool Nischalan Pillay Peter Van Loo Adrienne M Flanagan Genome Medicine Published 30 August 2022 Crick labsPeter Van LooFull details Pagination First page First Previous page Previous … Page 59 Page 60 Page 61 Page 62 Current page 63 Page 64 Page 65 Page 66 Page 67 … Next page Next Last page Last
Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome Authors (9) Jared R Thomas Jonathan LaCombe Rachel LongEva Lana-Elola Sheona Watson-Scales Joseph M Wallace Elizabeth MC FisherVictor Tybulewicz Randall J Roper Bone Published 1 July 2020 Crick labsVictor TybulewiczFull details
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018 Authors (18) Emi Takashita Rod S Daniels Seiichiro Fujisaki Vicki Gregory Larisa V Gubareva Weiijuan Huang[...] Herman Tse Dayan Wang Hui-Ling Yen Wenqing Zhang Adam Meijer Antiviral Research Published 1 March 2020 Crick labs/ facilitiesNicola LewisWorldwide Influenza CentreFull details
Tʜ17 cells transdifferentiate into regulatory T cells during resolution of inflammation Authors (23) Nicola Gagliani Maria Carolina Amezcua Vesely Andrea Iseppon Leonie Brockmann Hao Xu Noah W Palm[...] Jens GeginatBrigitta Stockinger Enric Esplugues Samuel Huber Richard A Flavell Nature Published 9 July 2015 Crick labsGitta StockingerFull details
Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation Authors (15) Motti Gerlic Benjamin Faustin Antonio Postigo Eric Chi-Wang Yu Martina Proell Naran Gombosuren[...] Arnold Satterthwait Robert C Liddington Shahram Salek-Ardakani Shu-ichi Matsuzawa John C Reed Proceedings of the National Academy of Sciences of the United States of America Published 7 May 2013 Crick labsMichael WayFull details
Increased skin papilloma formation in mice lacking glutathione transferase GSTP Authors (5) Colin J Henderson Kenneth J Ritchie Aileen McLaren Probir Chakravarty C Roland Wolf Cancer Research Published 15 November 2011 Crick labs/ facilitiesBioinformatics and BiostatisticsFull details
Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1) Authors (2)Eachan Johnson Luet-Lok Wong Catalysis Science and Technology Published 21 October 2016 Crick labsEachan JohnsonFull details
Optimisation of b-values for the accurate estimation of the apparent diffusion coefficient (ADC) in whole-body diffusion-weighted MRI in patients with metastatic melanoma Authors (9) Annemarie K Knill Matthew D Blackledge Andra Curcean James LarkinSamra Turajlic Angela Riddell Dow Mu Koh Christina Messiou Jessica M Winfield European Radiology Published 1 February 2023 Crick labsSamra TurajlicFull details
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's Authors (20) Christina E Toomey Wendy E HeywoodJames Evans Joanne Lachica Sarah N Pressey Sandrine C Foti[...] Tammaryn Lashley Steve M Gentleman Tamas Revesz Kevin MillsSonia Gandhi Acta Neuropathologica Communications Published 8 September 2022 Crick labsSonia GandhiFull details
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies Authors (8) Anna Olivieri Christine R Collins Fiona HackettChrislaine Withers-Martinez Joshua Marshall Helen R FlynnMark SkehelMichael Blackman PLOS Pathogens Published 1 December 2011 Crick labsMike BlackmanFull details
A genetic model for central chondrosarcoma evolution correlates with patient outcome Authors (23) William Cross Iben LyskjærTom LesluyesSteven Hargreaves Anna-Christina Strobl Christopher Davies[...] Genomics England Research Consortium Paul Cool Nischalan Pillay Peter Van Loo Adrienne M Flanagan Genome Medicine Published 30 August 2022 Crick labsPeter Van LooFull details