Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Search Results Fulltext search 891 Results Found Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity Authors (53) Catherine Riou Roanne Keeton Thandeka Moyo-Gwete Tandile Hermanus Prudence Kgagudi Richard Baguma[...] Alex Sigal Tamryn Smith Ziyaad Valley-Omar Dieter van der Westhuizen Kennedy Zvinairo Science Translational Medicine Published 9 February 2022 Crick labsRobert J WilkinsonFull details Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia Authors (23)Syed Mian Céline Philippe Eleni Maniati Pantelitsa Protopapa Tiffany BergotMarion Piganeau[...] Daniel H WisemanDominique Bonnet Delphine G Bernard John G Gribben Kevin Rouault-Pierre Science Translational Medicine Published 1 March 2023 Crick labsDominique BonnetFull details Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details Identification of DHODH as a therapeutic target in small cell lung cancer Authors (20)Leanne Li Sheng Rong Ng Caterina I Colón Benjamin J Drapkin Peggy P Hsu Zhaoqi Li[...] Mary Clare Beytagh Anna F Farago Matthew G Vander Heiden Nicholas J Dyson Tyler Jacks Science Translational Medicine Published 6 November 2019 Crick labsLeanne LiFull details A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms Authors (9) Emmanuel Griessinger Fernando Anjos-Afonso Irene Pizzitola Kevin Rouault-Pierre Jacques Vargaftig David Taussig John Gribben François LassaillyDominique Bonnet Stem Cells Translational Medicine Published 1 April 2014 Crick labsDominique BonnetFull details Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis Authors (52) Claire Vennin Venessa T Chin Sean C Warren Morghan C Lucas David Herrmann Astrid Magenau[...] Andrew Burgess Thomas R Cox Jennifer P Morton Marina Pajic Paul Timpson Science Translational Medicine Published 5 April 2017 Crick labs/ facilitiesLight MicroscopyFull details Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12)Miriam Molina ArcasChristopher MooreSareena RanaFebe VanMaldegem Edurne Mugarza Pablo Romero-Clavijo[...] Stuart Horswell Lian-Sheng Li Matthew R JanesDavid HancockJulian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesBiological Research FacilityAdvanced SequencingFull details Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition Authors (13) Roger A Habets Charles E de Bock Lutgarde Serneels Inge Lodewijckx Delphine Verbeke David Nittner[...] James Dooley Adrian Liston Tom Taghon Jan CoolsBart De Strooper Science Translational Medicine Published 29 May 2019 Crick labsBart de Strooper | Lorena ArancibiaFull details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details Pagination First page First Previous page Previous … Page 9 Page 10 Page 11 Page 12 Current page 13 Page 14 Page 15 Page 16 Page 17 … Next page Next Last page Last
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity Authors (53) Catherine Riou Roanne Keeton Thandeka Moyo-Gwete Tandile Hermanus Prudence Kgagudi Richard Baguma[...] Alex Sigal Tamryn Smith Ziyaad Valley-Omar Dieter van der Westhuizen Kennedy Zvinairo Science Translational Medicine Published 9 February 2022 Crick labsRobert J WilkinsonFull details
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia Authors (23)Syed Mian Céline Philippe Eleni Maniati Pantelitsa Protopapa Tiffany BergotMarion Piganeau[...] Daniel H WisemanDominique Bonnet Delphine G Bernard John G Gribben Kevin Rouault-Pierre Science Translational Medicine Published 1 March 2023 Crick labsDominique BonnetFull details
Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors Authors (35) Dennis Plenker Maximilian Riedel Johannes Brägelmann Marcel A DammertRakhee Chauhan Phillip P Knowles[...]Neil McDonald Stefan M Kast Oliver Gautschi Roman K Thomas Martin L Sos Science Translational Medicine Published 14 June 2017 Crick labsNeil McDonaldFull details
Identification of DHODH as a therapeutic target in small cell lung cancer Authors (20)Leanne Li Sheng Rong Ng Caterina I Colón Benjamin J Drapkin Peggy P Hsu Zhaoqi Li[...] Mary Clare Beytagh Anna F Farago Matthew G Vander Heiden Nicholas J Dyson Tyler Jacks Science Translational Medicine Published 6 November 2019 Crick labsLeanne LiFull details
A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms Authors (9) Emmanuel Griessinger Fernando Anjos-Afonso Irene Pizzitola Kevin Rouault-Pierre Jacques Vargaftig David Taussig John Gribben François LassaillyDominique Bonnet Stem Cells Translational Medicine Published 1 April 2014 Crick labsDominique BonnetFull details
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis Authors (52) Claire Vennin Venessa T Chin Sean C Warren Morghan C Lucas David Herrmann Astrid Magenau[...] Andrew Burgess Thomas R Cox Jennifer P Morton Marina Pajic Paul Timpson Science Translational Medicine Published 5 April 2017 Crick labs/ facilitiesLight MicroscopyFull details
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12)Miriam Molina ArcasChristopher MooreSareena RanaFebe VanMaldegem Edurne Mugarza Pablo Romero-Clavijo[...] Stuart Horswell Lian-Sheng Li Matthew R JanesDavid HancockJulian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilitiesJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsCell ServicesBiological Research FacilityAdvanced SequencingFull details
Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition Authors (13) Roger A Habets Charles E de Bock Lutgarde Serneels Inge Lodewijckx Delphine Verbeke David Nittner[...] James Dooley Adrian Liston Tom Taghon Jan CoolsBart De Strooper Science Translational Medicine Published 29 May 2019 Crick labsBart de Strooper | Lorena ArancibiaFull details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details