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Search Results Fulltext search 179 Results Found Legal Counsel Posted 17 Jan | Applications closed Breadcrumb Careers and study Vacancies Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12) Miriam Molina Arcas Christopher Moore Sareena Rana Febe VanMaldegem Edurne Mugarza Pablo Romero-Clavijo [...] Stuart Horswell Lian-Sheng Li Matthew R Janes David Hancock Julian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilities Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Genomics Cell Science Biological Research Facility Full details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14) William Grey Ana Rio-Machin Pedro Casado Eva Gronroos Sara Ali Juho J Miettinen [...] Charles Swanton Pedro R Cutillas John Gribben Jude Fitzgibbon Dominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilities Charles Swanton Dominique Bonnet Flow Cytometry Cell Science Biological Research Facility Full details Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20) Eva Lana-Elola Rifdat Aoidi Miriam Llorian Sopena Dorota Gibbins Callan Buechsenschuetz Claudio Bussi [...] Laurent Meijer Bram Snijders Maximiliano Gutierrez Elizabeth MC Fisher Victor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilities Victor Tybulewicz Maximiliano Gutierrez Proteomics Screening and Automated Science Bioinformatics and Biostatistics Full details The FAM13A long isoform regulates cilia movement and coordination in airway mucociliary transport Authors (31) Ashleigh Howes Clare Rogerson Nikolai Belyaev Tina Karagyozova Radu Rapiteanu Ricardo Fradique [...] Louise Walport Pietro Cicuta Andrew J Powell Soren Beinke Andreas Wack American Journal of Respiratory Cell and Molecular Biology Published 1 September 2024 Crick labs/ facilities Louise Walport Andreas Wack Translation team Bioinformatics and Biostatistics Light Microscopy Flow Cytometry Experimental Histopathology Full details MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition Authors (20) Gregor A Lueg James Zhang Monica Faronato Andrii Gorelik Wouter W Kallemeijn Francesco Falciani [...] Bernadette Brzezicha Martin Janz Louis Chesler Dinis Calado Edward W Tate Cell Reports Published 23 September 2025 Crick labs/ facilities Ed Tate Dinis Calado Translation team Proteomics In Vivo Imaging Flow Cytometry Biological Research Facility Bioinformatics and Biostatistics Full details EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers Authors (18) Marija Maric Sandra Segura-Bayona Raviprasad Kuthethur Tohru Takaki Valerie Borel Tyler Stanage [...] Scott Warchal Michael Howell Arnab Ray Chaudhuri Panagiotis Kotsantis Simon Boulton Nature Communications Published 26 September 2025 Crick labs/ facilities Simon Boulton Screening and Automated Science Bioinformatics and Biostatistics Translation team Genomics Flow Cytometry Cell Science Full details Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells Preprint Authors (18) Federica Raguseo Elliot Fellows Cesira De Chiara Benjamin Mortishire-Smith Sandra Segura-Bayona Emma Cawood [...] Mark Skehel Andrew J Powell David House Jacob T Bush Simon Boulton bioRxiv Published 11 June 2026 Crick labs/ facilities Katrin Rittinger Simon Boulton Translation team Proteomics Metabolomics Screening and Automated Science Structural Biology Cell Science Full details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21) Kevin Ng Nikhil Faulkner Katja Finsterbusch Mary Wu Ruth Harvey Saira Hussain [...] Michael Howell Hisashi Arase Andreas Wack David LV Bauer George Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilities Andreas Wack Charles Swanton Nicola Lewis George Kassiotis Sonia Gandhi Steve Gamblin Peter Cherepanov Rupert Beale David LV Bauer Worldwide Influenza Centre Structural Biology Screening and Automated Science Flow Cytometry Cell Science Biological Research Facility Full details Pagination First page First Previous page Previous … Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Current page 18
Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer Authors (12) Miriam Molina Arcas Christopher Moore Sareena Rana Febe VanMaldegem Edurne Mugarza Pablo Romero-Clavijo [...] Stuart Horswell Lian-Sheng Li Matthew R Janes David Hancock Julian Downward Science Translational Medicine Published 18 September 2019 Crick labs/ facilities Julian Downward Experimental Histopathology Bioinformatics and Biostatistics Genomics Cell Science Biological Research Facility Full details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14) William Grey Ana Rio-Machin Pedro Casado Eva Gronroos Sara Ali Juho J Miettinen [...] Charles Swanton Pedro R Cutillas John Gribben Jude Fitzgibbon Dominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilities Charles Swanton Dominique Bonnet Flow Cytometry Cell Science Biological Research Facility Full details
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20) Eva Lana-Elola Rifdat Aoidi Miriam Llorian Sopena Dorota Gibbins Callan Buechsenschuetz Claudio Bussi [...] Laurent Meijer Bram Snijders Maximiliano Gutierrez Elizabeth MC Fisher Victor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilities Victor Tybulewicz Maximiliano Gutierrez Proteomics Screening and Automated Science Bioinformatics and Biostatistics Full details
The FAM13A long isoform regulates cilia movement and coordination in airway mucociliary transport Authors (31) Ashleigh Howes Clare Rogerson Nikolai Belyaev Tina Karagyozova Radu Rapiteanu Ricardo Fradique [...] Louise Walport Pietro Cicuta Andrew J Powell Soren Beinke Andreas Wack American Journal of Respiratory Cell and Molecular Biology Published 1 September 2024 Crick labs/ facilities Louise Walport Andreas Wack Translation team Bioinformatics and Biostatistics Light Microscopy Flow Cytometry Experimental Histopathology Full details
MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition Authors (20) Gregor A Lueg James Zhang Monica Faronato Andrii Gorelik Wouter W Kallemeijn Francesco Falciani [...] Bernadette Brzezicha Martin Janz Louis Chesler Dinis Calado Edward W Tate Cell Reports Published 23 September 2025 Crick labs/ facilities Ed Tate Dinis Calado Translation team Proteomics In Vivo Imaging Flow Cytometry Biological Research Facility Bioinformatics and Biostatistics Full details
EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers Authors (18) Marija Maric Sandra Segura-Bayona Raviprasad Kuthethur Tohru Takaki Valerie Borel Tyler Stanage [...] Scott Warchal Michael Howell Arnab Ray Chaudhuri Panagiotis Kotsantis Simon Boulton Nature Communications Published 26 September 2025 Crick labs/ facilities Simon Boulton Screening and Automated Science Bioinformatics and Biostatistics Translation team Genomics Flow Cytometry Cell Science Full details
Phenotype-first covalent fragment screening identifies a synthetic lethal TYMS inhibitor in ATRX-deficient cells Preprint Authors (18) Federica Raguseo Elliot Fellows Cesira De Chiara Benjamin Mortishire-Smith Sandra Segura-Bayona Emma Cawood [...] Mark Skehel Andrew J Powell David House Jacob T Bush Simon Boulton bioRxiv Published 11 June 2026 Crick labs/ facilities Katrin Rittinger Simon Boulton Translation team Proteomics Metabolomics Screening and Automated Science Structural Biology Cell Science Full details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21) Kevin Ng Nikhil Faulkner Katja Finsterbusch Mary Wu Ruth Harvey Saira Hussain [...] Michael Howell Hisashi Arase Andreas Wack David LV Bauer George Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilities Andreas Wack Charles Swanton Nicola Lewis George Kassiotis Sonia Gandhi Steve Gamblin Peter Cherepanov Rupert Beale David LV Bauer Worldwide Influenza Centre Structural Biology Screening and Automated Science Flow Cytometry Cell Science Biological Research Facility Full details
